Circulating tumor cells
The Journal of Molecular Cancer is a broad-based journal found on two key tenets: To publish the most exciting research work in fields related to Journal of Clinical Research and Bioethics : Second to provide a rapid and quick reviewing and publishing of articles for research, teaching and reference purposes. It is basically aimed at the Clinical Practitioners, medical/ health practitioners, students, professionals and researchers and professional bodies and institutions.
Cancer metastasis is the leading cause of cancer-related death. Circulating tumor cells (CTCs) are shed into the bloodstream from either primary or metastatic tumors during an intermediate stage of metastasis. In recent years, immunotherapy has also become an important focus of cancer research. Thus, to study the relationship between CTCs and immunotherapy is extremely necessary and valuable to improve the treatment of cancer. In this review, based on the advancements of CTC isolation technologies, we mainly discuss the clinical applications of CTCs in cancer immunotherapy and the related immune mechanisms of CTC formation. In order to fully understand CTC formation, sufficiently and completely understood molecular mechanism based on the different immune cells is critical. This understanding is a promising avenue for the development of effective immunotherapeutic strategies targeting CTCs.
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Journal of Molecular Cancer
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